Urinary metabolites of chlorpropamide in dogs, rabbits, and man.

SummaryMetabolism of 1-(p-chlorobenzenesulfonyl)-3-n-propylurea was investigated in dog, rabbit and man. The rabbit excreted more than three-fourths of the drug without chemical alteration. Less than half of orally ingested drug was excreted unchanged by the dog, most of the remainder appeared as p-chlorobenzenesulfonylurea and p-chlorobenzenesulfonamide. As the result of a limited investigation in man, unchanged chlorpropamide and p-chlorobenzenesulfonamide were found in the urine. One other possible metabolite was indicated by paper chromatograms.