Clinical optical coherence tomography combined with multiphoton tomography for evaluation of several skin disorders
2010
The first clinical trial of optical coherence tomography (OCT) combined with multiphoton tomography (MPT) and
dermoscopy is reported. State-of-the-art (i) OCT systems for dermatology (e.g. multibeam swept source OCT), (ii) the
femtosecond laser multiphoton tomograph DermaInspectTM, and (iii) digital dermoscopes were applied to 47 patients
with a diversity of skin diseases and disorders such as skin cancer, psoriasis, hemangioma, connective tissue diseases,
pigmented lesions, and autoimmune bullous skin diseases. Dermoscopy, also called 'epiluminescent microscopy',
provides two-dimensional color images of the skin surface. OCT imaging is based on the detection of optical reflections
within the tissue measured interferometrically whereas nonlinear excitation of endogenous fluorophores and the second
harmonic generation are the bases of MPT images. OCT cross sectional "wide field" image provides a typical field of
view of 5 x 2 mm 2 and offers fast information on the depth and the volume of the investigated lesion. In comparison,
multiphoton tomography presents 0.36 x 0.36 mm 2 horizontal or diagonal sections of the region of interest within
seconds with submicron resolution and down to a tissue depth of 200 μm. The combination of OCT and MPT provides a
synergistic optical imaging modality for early detection of skin cancer and other skin diseases.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
2
Citations
NaN
KQI