Histology Data (10.1038/s41586-021-03835-2)

Histology data for Balaur et al. Nature, 2021MMTV - PyMT mouse data is denoted by the prefix "Mouse". There are 3 types of images H&E (hematoxylin and eosin), proliferative marker Ki67, and PL (plasmonically active microscope slide). The image type is indicated in the filename. The suffiix 20x or 4x indicates the objective used for imaging.MMTV-PyMT model: To confirm the timing of spontaneous development of mammary gland tumours in the C57 BL/6 MMTV-PyMT model, mammary glands of C57 BL/6 MMTV-PyMT mice (N=6) at different stages were taken and morphologically evaluated by H&E and Ki67 and Nanoslide (PL). Based on pathology diagnosis of cancer stage, results can be classified into four stages: ‘normal’, ‘hyperplasia’, ‘MIN’ and ‘invasive’.Mouse investigations were performed after approval by the La Trobe University Animal Ethics Committee.Human data is denoted by the suffix "human". There are 4 types of images H&E, cytokeratin 5 and 6 (CK 5/6) and theEoestrogen Receptor (ER), and Nanoslide (PL). The image type is indicated in the filename. The suffiix 20x or 4x indicates the objective used for imaging.Normal breast, UDH, DCIS and invasive breast cancer sections were obtained from routine diagnostic samples taken at RMH and Austin Health (N = 24 patients) under Human Research Ethics Committee approval (HREC 2017.336 and HREC/14/Austin/425). For HREC/14/Austin/425, patients consented to their tissue (stored or future) being used in translational research. Aconsent waiver was granted by the HREC as part of 2017.336 for retrospective use of tissues for research purposes.