Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression

Muhammad S. Alam,Matthias M. Gaida,Frank Bergmann,Felix Lasitschka,Thomas Giese,Nathalia A. Giese,Thilo Hackert,Ulf Hinz,S. Perwez Hussain,Serguei V. Kozlov,Jonathan D. Ashwell

Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression

2015

Muhammad S. Alam
Matthias M. Gaida
Frank Bergmann
Felix Lasitschka
Thomas Giese
Nathalia A. Giese
Thilo Hackert
Ulf Hinz
S. Perwez Hussain
Serguei V. Kozlov
Jonathan D. Ashwell

Blocking alternative activation of p38 in tumor-infiltrating CD4+ T cells reduces proinflammatory cytokine production and inhibits pancreatic cancer growth in mice.

Keywords:

Interleukin 10
Immunology
Pancreatic cancer
Proinflammatory cytokine
Interleukin 17
Tumor necrosis factor alpha
Phosphorylation
Signal transduction
Biology
p38 mitogen-activated protein kinases
Medicine

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