Deferasirox-tacrine metal ion chelating agent and pharmaceutical use thereof

2015 
The invention provides a deferasirox-tacrine metal ion chelating agent, the structural formula of which is shown as formula I. The invention also provides a preparation method of the deferasirox-tacrine metal ion chelating agent and application of the chelating agent in preparation of drugs treating Alzheimer's disease. According to the invention, deferasirox and tacrine are connected together through carbon chains of different lengths, the metal-chelating properties and antioxidant properties of deferasirox are reserved, and the connected tacrine matrix retains the original acetylcholine esterase inhibitory activity. The obtained novel ion chelating agent has multiple functions and can act on multiple target points. (formula I).
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