Central Autonomic Dysorganization in the Early Stages of Experimental Meningitis in Rabbits Induced by Complement-C5A-Fragment: A Pathophysiological Validation of the Largest Lyapunov Exponent of Heart Rate Dynamics

In a study of central autonomic organization in early stages of experimental meningitis in rabbits, the temporal oscillations of the momentary heart rate (heart rate dynamics) were measured. In 10 anesthetized rabbits an experimental meningitis was induced by intracisternal injection of complement-C5a-fragment in a carrier solution of sodium chloride and bovine serum albumin. 10 rabbits were injected with the above carrier solution only and served as controls. The temporal structure of the heart rate dynamics was operationalized phase-space analytically through the estimation of the largest Lyapunov exponent. Without exception, positive Lyapunov exponents of the heart rate dynamics were found, which revealed chaotic oscillations. In contrast to the controls, the intracisternal injection of C5a caused a significant decrease of the analytical index and reduced its reproducibility significantly. This result suggests a subtle central-autonomic dysfunction and a loss of the autonomic steady-state induced by th...