Síndrome colestásico neonatal prolongado secundario a panhipopituitarismo. Informe de un caso y revisión de la literatura

Prolonged neonatal cholestasis syndrome has several etiologies, some of them are endocrinological; one of these includes hypopituitarism which is infrequent and whose incidence is unknown. Although isolated cases have been reported worldwide, there are no reports in Mexico. We present the case of a 28 day-old male who was admitted to our service with cholestasis and hypoglycemia. A hypophyseal hormone deficiency was documented. Hormone replacement therapy was started, which resulted in remission of symptomatology. Physiopathology of hypopituitarism cholestasis is unclear. However, it is believed that the deficit of growth hormone may alter liver function decreasing biliary salt synthesis and altering the biliary duct structure. The importance of this case stems from the fact that this etiology should be intentionally