Vandetanib hydrate crystal and preparation method thereof

The invention belongs to the field of medicine, and discloses a vandetanib hydrate crystal and a preparation method thereof. The vandetanib hydrate crystal provided by the invention is a vandetanib trihydrate crystal. For the hydrate crystal, feature diffraction peaks are shown in positions being 2.83 degrees, 4.72 degrees, 7.34 degrees, 7.78 degrees, 10.08 degrees, 12.10 degrees, 13.68 degrees, 17.13 degrees, 26.26 degrees, 28.75 degrees, 33.52 degrees, 34.76 degrees and 37.33 degrees in an X-ray powder diffraction atlas shown by a diffraction angle of 2theta+/-0.2 degrees. The X-ray powder diffraction atlas obtained by using the Cu-Ka ray for measurement is shown as Figure 1, and is completely different from that in the prior art. The vandetanib hydrate crystal provided by the invention has high flowability, high solubility and high stability, and is very suitable for clinic application. The invention also discloses a preparation method of the hydrate crystal; the preparation method is simple and mild, and is suitable for industrial mass production.