[Expression and significance of glypican-3 in colorectal cancer].

Objective To investigate the expression and significance of Glypican-3 in colorectal cancer.Methods Immunohistochemistry was used to detect the expression of Glypican-3 in 200 specimens of colorectal cancer and adjacent non-cancerous tissues resected during operation.Results Glypican-3 immunoreactivity was recognized in both the cytoplasm and cellular membrane.The Glypican-3 positive expression rate in the tumor samples Was 66.0% (132/200),significantly higher than that in the adjacent nontumor tissues(24%,48/200,P=0.019).The Glypican-3 expression rate was significantly correlated with the carcinoma invasion (P=0.023) and lymph node metastasis (P=0.015),but not associated with gender,age,tumor size,and difierentiation grade (all P>0.05).Conclusion Over-expression of Glypican-3 may play an important role in the genesis and development of colorectal cancer,and may be used as a new biological parameter in predicting invasion and metastasis of colorectal carcinoma. Key words: Intestinal neoplasms;  Immunohistochemistry;  Glypican-3