Development and validation of an LC–MS/MS method for the bioanalysis of the major metamizole metabolites in human plasma

Fabio Bachmann,Lea S. Blaser,Manuel Haschke,Stephan Krähenbühl,Urs Duthaler

Development and validation of an LC–MS/MS method for the bioanalysis of the major metamizole metabolites in human plasma

2020

Fabio Bachmann
Lea S. Blaser
Manuel Haschke
Stephan Krähenbühl
Urs Duthaler

Aim: Metamizole is a frequently used antipyretic and analgesic prodrug, yet its pharmacokinetics has not been thoroughly studied in infants and with coadministered medications. Thus, an LC–MS/MS me...

Keywords:

Bioanalysis
Chromatography
Liquid chromatography–mass spectrometry
Prodrug
Antipyretic
Analgesic
Chemistry
Metamizole
Pharmacokinetics
lc ms ms
human plasma

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