THU0453 PROGRESSION OF PAIN, NUMBER OF PAINFUL AND SWOLLEN JOINTS AND ULTRASOUND DETECTED CHANGES IN THE GROUP OF 133 PATIENTS WITH HAND OSTEOARTHRITIS OVER THREE YEARS

Background Hand osteoarthritis (HOA) is a common and frequent cause of pain. HOA is a heterogeneous group of disorders with two main subsets including non-erosive and erosive disease. Few studies demonstrated inflammatory ultrasound changes and more severe clinical symptoms in patients with erosive compared with non-erosive disease, however the results are inconsistent. Objectives The aim of this study was to evaluate progression of pain, stiffness, physical impairment and ultrasound features in patients with erosive and non-erosive HOA in a three years longitudinal study. Methods Consecutive patients with symptomatic HOA fulfilling the American College of Rheumatology (ACR) criteria were included in this study. Joint pain and swelling were assessed. Patients reported joint pain on 100 mm visual analogue scale (VAS). Pain, joint stiffness and disability were assessed by the Australian/Canadian OA hand index (AUSCAN). Radiographs of both hands were examined, and erosive disease was defined by at least one erosive interphalangeal joint. Synovial hypertrophy and power Doppler signal (PDS) were scored with ultrasound. Synovitis was graded on a scale of 0–3 and osteophytes were defined as cortical protrusions seen in two planes. Patients were examined at baseline and at the first, second and third year of follow-up. Results Altogether, 133 patients (14 male) with symptomatic nodal HOA were included in this study and followed between April 2012 and January 2019. Out of these patients, 72 (6 male) had erosive disease. The disease duration (p Pain reported on VAS was significantly higher (p According to the AUSCAN, patients with erosive compared with non-erosive disease had more pain (p US-detected pathologies such as gray-scale synovitis (p Conclusion The findings of this study show that pain and number of painful and clinically swollen joints associated with US-detected synovial changes and osteophyte formation is more severe in patients with erosive HOA than in patients with non-erosive disease. In addition, osteophyte formation is more likely to progress independent of synovial inflammation. Reference [1] Meersseman P, Van de Vyver C, Verbruggen G, et al. Clinical and radiological factors associated with erosive radiographic progression in hand osteoarthritis. Osteoarthritis and Cartilage 2015;23:2129-2133. Acknowledgement This work was supported by the project MHCR 023728 and AZV No. 18-00542. Disclosure of Interests Olga Sleglova: None declared, Olga Růžickova: None declared, Karel Pavelka: None declared, Ladislav Senolt Grant/research support from: AbbVie, Consultant for: AbbVie, Bristol-Myers Squibb, Celgene Corporation, Merck Sharp and Dohme, Novartis, Pfizer, Roche, UCB, Amgen, Takeda, Speakers bureau: AbbVie, Amgen, Bristol-Myers Squibb, Celgene Corporation, Eli Lilly, Merck Sharp and Dohme, Novartis, Pfizer, Roche, UCB