Enlarged perivascular spaces and its clinical significance

A number of studies have shown that the enlarged perivascular spaces (EPVS) are associated with various diseases such as cerebral small vessel disease, Alzheimer's disease, post-stroke depression, and post-stroke cognitive impairment. This article reviews the imaging features, pathophysiological mechanisms and clinical significance of EPVS. Key words: Cerebral small vessel diseases; Magnetic resonance imaging; Microvessels; Dilatation, pathologic; Stroke; Brain ischemia; Hypertension; Alzheimer's disease; Risk factors