Effect of aebroxol on The Pharmacokientice of Roxithromycin in Rats

OBJECTIVE:In order to evaluate the interactions and rationality of drug combination in clinic between Amb and RM,the influences of Amb on the pharmacokinetic parameters of RM in rats were investigated in this research. METHOD:72 SD rats were randomly divided into 4 groups.The RM was given to the control group while Amb which were at doses of 2.7mg· kg-1,5.4 mg·kg-1,10.8 mg·kg-1 were given to experimental group Ⅰ,Ⅱ and Ⅲfor 6 days,and given together with RM at the seventh day respectively.Blood samples were collected by orbital plexus.The RM concentrations in the plasma were determinated by HPLC-UV,and the pharmacokinetic parameters of RM were calculated by DAS 2.1.1. RESULTS:The results showed that there were no significant differences on the main pharmacokinetic parameters of RM such as Tmax,T1/2z,Cmax,Vz,CLz,AUC0～t and AUC0～∞ between the experimental groups and the control group(p0.05). CONCLUSION:The Amb did not have significant influences on the pharmacokinetic of RM in rats.It is safe to use the combination of the two drugs and there is no need to adjust the dosage of RM.This study provided a certain experimental evidence for clinical use of RM when co-administrated with Amb.