Meroditerpene pyrone, tryptoquivaline and brasiliamide derivatives from the fungus Neosartorya pseudofischeri

Abstract Two new meroditerpene pyrones, chevalone F ( 1 ) and 11-hydroxychevalone E ( 2 ), a new tryptoquivaline analog, tryptoquivaline V ( 3 ) and a new brasiliamide analog, brasiliamide G ( 4 ), together with thirteen known compounds, chevalones A-C ( 5–7 ), chevalone E ( 8 ), 11-hydroxychevalone C ( 9 ), pyripyropene A ( 10 ), isochaetominine C ( 11 ), pyrrolobenzoxazine terpenoids CJ-12662 ( 12 ) and CJ-12663 ( 13 ), fischerindoline ( 14 ), eurochevalierine ( 15 ), 1,4-diacetyl-2,5-dibenzylpiperazine-3,7′′-oxide ( 16 ) and lecanorin ( 17 ) were isolated from the fungus Neosartorya pseudofischeri . Their structures were established on the basis of spectroscopic evidence. Compound 2 showed weak antibacterial activity against Escherichia coli and Salmonella enterica serovar Typhimurium, whereas compounds 7 , 12 , 13 and 15 showed antibacterial activity against Bacillus cereus and Staphylococcus aureus . In addition, compounds 13 and 14 showed cytotoxicity against KB and MCF-7 cancer cell lines, as well as the Vero cell line.