Outcome analysis of primary liver carcinomas.

438 Background: Treatments for hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHCCa) are established. Significant debate exists over optimal treatment for biphenotypic primary liver carcinomas (PLC) with combined HCC and IHCCa (B-PLC) and is considered to be a contraindication for transplantation. The purpose of this analysis is to determine single center outcomes of patients with B-PLC compared to HCC and IHCCa. Methods: A prospective database was reviewed to determine treatments and survivals of patients with HCC, IHCCa and B-PLC. Results: From 1/1/2009 to 12/31/2014, 810 patients with PLC were treated with resection (LRx) (n = 117), liver transplant (OLT) (n = 224) or liver directed therapy (LDT) (n = 469). 723 patients had HCC, 34 had IHCCa and 53 had B-PLC. Overall Survival (OS) in the LDT group, was similar comparing all tumor types at 1 yr (61.7%) and 3 yrs. (23.8%) (p =.3) Median survival (MS) was 16.2 months. OS in the LRx group was also similar between tumor types (1yr 81.1%...