Effect of early intervention of hyperbaric oxygenation on prognosis of perinatal neonates with hypoxic ischemic encephalopathy

Objective:To observe the effect of early intervention of hyperbaric oxygenation (HBO) on prognosis of perinatal neonates with hypoxic ischemic encephalopathy (HIE),and explore the effective prevention and cure methods of sequelae related to HIE.Methods:84 neonates with HIE who were hospitalized and diagnosed at the Department of Neonatology,Zhongshan Hospital from January 2002 to October 2005 were selected and divided into control group and treatment group randomly.The neonates in the two groups were given routine three items of maintenance treatment,three items of symptomatic treatment and cerebrolysin treatment at early stage.On the basis of basic treatment,the neonates in treatment group received two courses of HBO treatment,then neurological assessment was conducted before treatment and one course after treatment by Chinese twenty items of Neonatal Behavioral Neurological Assessment (NBNA) scale.All the neonates were followed up for 12 months,and cranial CT reexamination was carried out,motion development was observed and Gesell intelligence DQ was checked.Results:82 neonates were followed up for 12 months.There was no significant difference in NBNA score before treatment between the two groups,but after treatment,NBNA score in treatment group (38.8±2.3) was significantly higher than that in control group (34.6±2.2) (P0.01).The incidence of cerebral dysplasia in treatment group was 7.14% (3/42),which was significantly lower than that in control group (25.0%,10/40,P0.05).The scores of intelligence DQ in the two groups:the score of action ability in treatment group was significantly higher than that in control group (106.8±10.3,89.8±11.1,P0.01); the ability responding to object in treatment group was significantly higher than that in control group ( 102.3±11.6,87.7±11.9,P0.01); the ability responding to human in treatment group was significantly higher than that in control group (105.6±11.4,90.2±11.3,P0.01); language ability in treatment group was significantly higher than that in control group ( 98.8±11.9,91.6±10.3,P0.01).Conclusion:Early intervention of HBO can promote cerebral development,raise neonatal NBNA score and intelligence DQ,and improve the prognosis of neonates with HIE.