Роль цитокиновой системы RANKL/RANK/OPG в регуляции минерального обмена костной ткани

The review describes the modern data concerning the cellular and molecular mechanisms of mineral metabolism disturbance in bone tissue. Cytokine system consisting of receptor activator of nuclear factor κ-b, its ligand and osteoprotegerin (RANKL/RANK/OPG) has a key role in understanding of bone remodeling regulation. We discuss a significance of the cytokine system in osteoblastoand osteoclastogenesis. Molecular processes of histogenesis and bone resorption have been analyzed.