CD30+ expression in Peripheral T-cell lymphomas (PTCLs): A subset analysis from the international, prospective T-Cell Project.

8552 Background: CD30 is a member of TNF-alpha receptor family that might have important therapeutic implications with the advent of targeted therapies. Several PTCLs subtypes have been reported in literature to be associated to variable CD30 expression. We investigated the frequency of CD30 expression among PTCLs subtypes registered in the T-Cell Project and correlated it with clinical features and outcome. Methods: The T-cell Project is a prospective, international study in patients (pts) with newly diagnosed aggressive PTCLs. Clinical, laboratory and disease localization data at diagnosis as well as therapy details and follow-up information are collected at a dedicated website via secure HTTP protocols. Central review of diagnostic biopsy is planned. Results: From Sept 2006 to Jan 2015, 1308 pts were registered in the T-Cell Project by 73 sites from 14 countries world-wide. As from the 792 pathology forms filled out by site local staff CD30 expression was tested in 490 pts (62%) and reported as CD30+ i...