The structure of the Ca 2+ -ATPase of sarcoplasmic reticulum

In this article the morphology of sarcoplasmic reticulum, classification of Ca 2+ -ATPase (SERCA) isoenzymes presented in this membrane system, as well as their topology will be reviewed. The focus is on the structure and interactions of Ca 2+ -ATPase determined by electron and X-ray crystallography, lamellar X-ray and neutron diffraction analysis of the profile structure of Ca 2+ -ATPase in sarcoplasmic reticulum multilayers. In addition, targeting of the Ca 2+ -ATPase to the sarcoplasmic reticulum is discussed.