Evaluation of regulatory T lymphocytes and IL2Ra and FOXP3 gene expression in peripheral mononuclear cells from patients with amyotrophic lateral sclerosis

Sara Rashid Chehreh Bargh,Abbas Tafakhori,Farimah Masoumi,Farzaneh Rahmani,Mona Ahmadi,Afshin Namdar,Maryam Azimi,Parsova Tavasolian,Sima Habibi,Babak Zamani,Marziyeh Maserrat,Maryam Sadr,Farshid Noorbakhsh,Nima Rezaei

Evaluation of regulatory T lymphocytes and IL2Ra and FOXP3 gene expression in peripheral mononuclear cells from patients with amyotrophic lateral sclerosis

2018

Sara Rashid Chehreh Bargh
Abbas Tafakhori
Farimah Masoumi
Farzaneh Rahmani
Mona Ahmadi
Afshin Namdar
Maryam Azimi
Parsova Tavasolian
Sima Habibi
Babak Zamani
Marziyeh Maserrat
Maryam Sadr
Farshid Noorbakhsh
Nima Rezaei

Background Loss of neuroprotective role of CD4+ helper T cells, regulatory T cells, and M2 microglia constitutively results in the rapid neural death in the “rapidly progressive phase” of amyotrophic lateral sclerosis (ALS).

Keywords:

FOXP3
Surgery
IL-2 receptor
Microglia
Amyotrophic lateral sclerosis
Regulatory T cell
Immunology
Neuroprotection
Diabetes mellitus
Peripheral blood mononuclear cell
Medicine
Peripheral
Cancer research

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