2,2′-Bipyridine and hydrazide containing peptides for cyclization and complex quaternary structural control
2018
A synthetic peptide containing two Ne-methyl lysines (Ac-K(Ne-Me)GYTGYTGK(Ne-Me)D-OH) was alkylated with bipyridine (bipy) ligands substituted at the fifth (MP-5) and sixth (MP-6) positions, thereby creating Ac-K(Ne-Me, Ne-Bipy)GYTGYTGK(Ne-Me, Ne-Bipy)D-OH. Peptides with a bipyridine at the 6-position did not bind to Fe2+ and Zn2+. Peptides with a bipyridine at the 5-position bound these metals, and in the presence of one equivalent of a free bipy derivative folded into a macrocycle. Further, the free bipy derivative could also contain a cyclized peptide derived from hydrazone formation, resulting in a complex but controlled quaternary peptide structure.
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