A case report of Menetrier’s disease

Menetrier’s disease (MD) is a rare premalignant disorder of unknown etiology, characterized by giant hypertrophic folds involving fundus, with antral sparing. Microscopy shows hyperplasia and corkscrew appearance of gastric foveolae, often associated with prominent eosinophilic inflammatory infiltrate. Common presentation is pain, vomiting, diarrhea and hypoproteinemia. Differential diagnoses include polyposis and infiltrating disorders, and gastrectomy recommended if debilitating disease or risk of carcinoma. A 50-year-old male presented with abdominal pain, vomiting and hypoproteinemia. Radiology and endoscopy showed thickened gastric folds and biopsy suggested a possibility of eosinophilic gastritis or MD. Total gastrectomy specimen and microscopy showed a classical appearance of MD. Exact incidence of MD in India is not known. Diagnosis can be missed on biopsy and adequate sampling with follow-up is essential due to associated risk of malignancy. DOI: 10.21276/APALM.1622