Pengaruh Suplementasi Vitamin C dan Multivitamin Mineral Terhadap Status Gizi, Kesehatan, dan Fungsi Ginjal

FEBRINA SULISTIAWATI. The Effect of Vitamin C and Multivitamin Mineral Supplementation on Nutritional Status, the Health, and Renal Function. Under direction of RIMBAWAN and DADANG SUKANDAR. Use of vitamin C and multivitamin mineral (MVM) supplement has grown rapidly over the past several decades. According to several studies, supplement users tend to have higher micronutrient intakes from their diet than nonusers. Consequently, they have an increased intake but are also more likely to exceed the upper level. The study was aimed to analyze the effect of vitamin C and MVM supplementation on nutritional status, the health, and renal function through the double blind randomized controlled trial. Subjects were 93 of the female workers in PT Ricky Putra Globalindo Tbk, Citeureup, Bogor who were randomly allocated to three treatments. The first received only placebo (without vitamin C and MVM); the second received 1000 mg vitamin C; and the third received MVM supplement that contains 1000 mg vitamin C, 45 mg vitamin E, 700 g vitamin A, 6,5 mg vitamin B6, 400 g folic acid, 9,6 g vitamin B12, 10 g vitamin D, 10 mg Zn, 110 g Se, 0,9 mg Cu, and 5 mg Fe. The supplements were distributed and consumed daily during 10 weeks. The effect of treatments on nutritional status based on body mass index (BMI), the health status based on systolic and diastolic blood pressure, and the renal function based on urea and cretainine blood serum were tested with Ancova. The results showed the BMI, systolic and diastolic blood pressure, and urea were not significantly different among the three treatments (p>0,05); the creatinine was significantly different (p<0,05) on vitamin C and MVM treatments, but still on the normal range. The distribution of female workers based on BMI showed that more than half of them have normal nutritional status (BMI 18,5-24,9 kg/m 2 ). The distribution based on systolic and diastolic blood pressure showed that most of them were not hypertension (systolic <140 mmHg, diastolic <90 mmHg); and the distribution based on urea and creatinine showed that most of them have normal status (urea 8,0-25,0 mg/dl; creatinine 0,6-1,5 mg/dl).