Effect of Sleep Deprivation on Learning-memory and Hippocampal IL-1β in Rats and the Role of SB203580 Intervention

Objective To investigate the effects of sleep deprivation (SD) on learning-memory and hippocampal IL-1β in Rats and the role of SB203580 intervention.Methods Male Sprague- Dawley rats were randomly divided into three groups: control,model,SB203580-treated groups.SD models were established by the modified multiple platform methods.Morphological changes were observed with light microscopy.The IL-1β expression was examined by immunohistochemistry and Western blot.Learning and memory function was monitored with Morris water maze.Results Compared with control group,neuronal structure was obviously damaged,the density of survival neurons decreased,the IL-1β expression increased and learning and memory function significantly decreased with time of SD in model group.Compared with model group,the density of survival neurons was increased,IL-1β expression obviously decreased,but the ability of learning and memory function enhanced in SB203580-treated group (P 0.05).Conclusions SD could increase IL-1β expression and finally result in cognition injury.However,SB203580 improved learning-memory function by attenuating IL-1β expression.