A five year histopathological study of granulomatous lesions at a tertiary care centre

Introduction: Granulomas are common findings in biopsy of various organs. Granulomas are a characteristically focal circumscribed collection of histiocytes along with lymphocytes and giant cells. Objectives: Present study was undertaken to note the frequency and etiology of granulomatous inflammation in various organs by means of histopathology examination. Materials and Methods: The prospective study was conducted for five years (January 2011- December 2015) in pathology department of a medical college hospital. The study includes total 510 biopsies which were showing granulomatous origin. Results: Out of 510 total biopsies, largest number 430 biopsies diagnosed as tubercular inflammation (84.31%), followed by leprosy (5.09%), fungal origin (2.74%), parasitic (1.32%) and cases of granuloma of unknown etiology (1.78%). Conclusion: Most of the granuloma are of infective origin and tubercular granuloma is most common type of etiology in biopsies which shows granulomatous inflammation and lymphnode is the most common affected site. Key words: Granulomatous inflammation, Tuberculosis, Histopathological examination, ZN staining.