Novel chiral sulfinamide phosphines: valuable precursors to chiral β-aminophosphines
2016
Abstract Starting from commercially available aldehyde and chiral tert -butanesulfinamide, a series of chiral sulfinamide phosphines ( Xiao-Phos ) were synthesized via a two-step condensation-nucleophilic addition procedure. In most cases, nucleophilic addition of the N - tert -butanesulfinyl imine with diphenyl methyl phosphonic lithium showed high diastereoselectivity (d.r>20:1) with BF 3 as additives. Following removal of the chiral auxilliary, an important class of ligands i.e chiral β-aminophosphines and its derivatives were obtained in high yields using this approach.
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