IFNα kinoid vaccine in conjunction with tritherapy, a weapon to combat immunopathogenesis in AIDS

Summary Antiviral therapy, including antiprotease treatment, suppresses viral replication, but it does not restore the HIV-1 induced immunopathogenesis which includes IFNα overproduction and cellular immunosuppression. To combat HIV-1 induced immunopathogenesis, anti-IFNα kinoid immunization in combination with tritherapy may be beneficial to HIV-1 infected immunodeficient patients.