INFLUENCE OF LIPID PEROXIDATION PROCESSES ON OXYGEN-TRANSPORT PROPERTIES OF HEMOGLOBIN IN ERYTHROCYTES OF PERIPHERAL BLOOD OF PREGNANT WOMEN WITH CYTOMEGALOVIRUS INFECTION

Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS, Blagoveshchensk The article is devoted to the study of activity of lipid peroxidation processes and their influence on oxygen-transport properties of hemoglobin in erythrocytes of peripheral blood of pregnant women with cytomegalovirus infection. Activation of lipid peroxidation processes in pregnant women with cytomegalovirus infection determined by the contents of TBA-active products is accompanied by accumulation of cytotoxic factors – arachidonic acid (I trimester – up by 31 %, II trimester – up by 68 %, III trimester – up by 41 %) and lysophosphatidylcholine (I trimester – up by 85 %, II trimester – up by 55 %, III trimester – up by 13 %), causes disorders of oxygen-transport properties of hemoglobin in erythrocytes (decrease of total erythrocytes and hemoglobin count), more than double increase of indices of thermolabile hemoglobin at slight decrease of oxyhemoglobin, increase of methemoglobin (I trimester – up by 60 %, II trimester – up by 25 %, III trimester – up by 16 %, in comparison with control), that causes decrease of transportation and delivery of oxygen to the tissues and can be the reason of hypoxia.