Antibacterial and synergistic effect of honey and cocoa extract against extended spectrum Beta lactamase producing Escherichia coli

Extended spectrum Beta lactamase producing Escherichia coli has become a serious clinical problem worldwide, due to its ability of hydrolyzing beta lactams antibiotics. This consequently increases the cost of medication. This study was aimed at determining the antibacterial and synergistic effect of concoction and decoctions of honey and cocoa extract using disc diffusion and tube dilution methods. Results of this study, suggest that, both the concoction and decoctions had marked antibacterial activity. However, the concoction was found to be significantly efficacious against the ESBL producing Escherichia coli than the decoctions (F= 583.630, P <0.05). It was therefore, concluded, that the combination of this agents may be useful in the treatment of infection caused by such isolates.