Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.

Stefanie Flunkert,Michael Hierzer,Tina Löffler,Roland Rabl,Joerg Neddens,Stephan Duller,Emma Schofield,Malcolm Ward,Maria Posch,Helmut Jungwirth,Manfred Windisch,Birgit Hutter-Paier

Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.

2013

Stefanie Flunkert
Michael Hierzer
Tina Löffler
Roland Rabl
Joerg Neddens
Stephan Duller
Emma Schofield
Malcolm Ward
Maria Posch
Helmut Jungwirth
Manfred Windisch
Birgit Hutter-Paier

Tauopathies, characterized by hyperphosphorylation and aggregation of tau protein, include frontotemporal dementias and Alzheimer's disease. To explore disease mechanisms and investigate potential tre

Keywords:

Pathology
Tau protein
Phosphorylation
Hyperphosphorylation
Tauopathy
Genetically modified mouse
Biology
Diabetes mellitus
disease mechanisms
Neuroscience
Disease

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