IRILmap: linkage map distance correction for intermated recombinant inbred lines/advanced recombinant inbred strains

Summary: Intermated Recombinant Inbred Lines (IRILs) in plants, or Advanced Recombinant Inbred Strains in animals, are constructed by carrying out generations of intermating between F2 individuals before starting recurrent inbreeding generations by selfing or sib-mating. IRILs are powerful for high-resolution genetic mapping because they have undergone more recombination than usual Recombinant Inbred Lines (RILs). However, there is no mapping software able to generate actual centiMorgan distances from the segregation data obtained with IRILs. IRILmap software converts genetic distances computed with any linkage mapping program designed for RILs, so that IRIL-derived data can be used to get actual centiMorgan distances, directly comparable to F2, backcross or RIL-derived maps. Availability: IRILmap is available with a user-friendly interface on Microsoft Windows operating systems, and as a perl v5.6.1 script with a minimal interface, for command-line use on any platform, or embedding in other applications. Both versions are freely available at http://moulon.inra.fr/~bioinfo/mapping/irilmap1.html Contact: falque@moulon.inra.fr