Correlation of serum osteoprotegerin levels and bone mineral density early after parathyroidectomy in hemodialysis patients

In patients with renal insufficiency, the variety of metabolic bone diseases occur which caused by vitamin D metabolism and parathyroid disorders. OPG is a member of issue necrosis factor receptor gene family. In dialysis patients the OPG values are higher than the normal range so it could affect the parathyroid hormone metabolism pathway through its inhibitory activities on the osteoclasts. The aim of this study was to investigate the relationship between OPG serum levels and bone mineral density status in dialysis patients after the parathyroidectomy surgery. In Nephrology Section of Internal Medicine Department of Tabriz University Medical Sciences, the cross-sectional descriptive analysis study was conducted on long-term hemodialysis patients with secondary hyperparathyroidism resistant to treatment and the relationship between OPG serum levels and bone mineral density status in dialysis patients after the parathyroidectomy surgery was investigated. There was no significant relationship between OPG level with PTH and age of the patients undergoing parathyroidectomy. In patients, the level of OPG (four months after parathyroidectomy) was significantly lower than its level before the surgery which represented a significant decrease in OPG level (four months after parathyroidectomy) compared to its level before the surgery. (P<0.001). Before and after the parathyroidectomy, there was no significant relationship among OPG level of the patients and their PTH level. The patients' BMD increased after parathyroidectomy which indicated the positive effect of this surgery on their bone density.