DISSOLUTION RATE ENHANCEMENT AND PHYSICOCHEMICAL CHARACTERIZATION OF NAFTOPIDIL IN SOLID DISPERSIONS WITH Β-CD AND HP Β-CD

Article history Received 31/12/2014 Available online 1503/2015 Naftopidil, (R,S)-l-((2-methoxyphenyl)-l-piperazinyl)-3-(l-naphthyloxy)2-propanol, is a novel antihypertensive agent. Naftopidil is practically insoluble in water. The present study was carried out to enhance dissolution properties of naftopidil through the preparation of solid dispersions using β-cyclodextrine (β-CD) and hydroxy propyl β-cyclodextrine (HP β-CD) as carrier at various proportions by using kneading method and by the physical mixture method. Solid dispersions of Naftopidil with carriers were prepared in different drug: carrier ratios such as (1:1, 1:3, 1:5) using techniques like physical mixing (PM) and kneading method (KM). The drug release profile was studied in pH 1.2 HCl solution. The DSC and FTIR analysis was carried out to study the compatibility between drug and carrier. UV spectrophotometric method was selected for assay as well as in-vitro dissolution studies at 280nm. The solid dispersion using HP β-CD and napthopidil exhibited superior dissolution profile than pure drug.