Окислительная модификация липидов и протеинов при осложнении коронарного атеросклероза

Relationships of lipids and proteins oxidative modifications with disturbances of hemostasis and of endothelial Junction in coronary atherosclerosis complication acute myocardial infarction (MI) were studied. The oxidative modification of fibrinogen is 1,7 times higher in acute MI men in comparison with men without coronary heart disease. Increased oxidized fibrinogen level is correlated with increased levels of lipid peroxidation products in plasma and in low density lipoproteins, Willebrand factor, fibrin degradation products, with accelerated leukocyte-platelet aggregation, decreased of plasma NO metabolites level and delayed activity of Hageman-dependent fibrinolysis. Dependent associations of oxidized fibrinogen level with MI and parameters of typical thrombosis and hypercoagulatory hemostasis disturbances and endothelial function were revealed.