One kind of a fully human antibody Fab and an anti-TLR4 antibody IgG whole molecule and Applications

The present invention relates to a fully human antibody Fab and an anti-IgG whole molecule of TLR4 and applications, the full amino acid sequence of the antibody molecule IgG light chain shown in SEQ ID NO.11 is the amino acid sequence of the heavy chain is SEQ ID NO .12 shown. In vitro experimental results show that the present invention is the source of fully human anti-TLR4 antibody IgG whole molecule, and can effectively identify the native recombinant protein TLR4, and can block the expression of TNF-α induced by LPS in THP-1 cells, inhibition rate was 85.7%.