Induction of cell cycle arrest and inflammatory genes by combined treatment with epigenetic, differentiating, and chemotherapeutic agents in triple-negative breast cancer

Vanessa F. Merino,Soonweng Cho,Nguyen Nguyen,Helen Sadik,Athira Narayan,C. Conover Talbot,Leslie Cope,Xian C. Zhou,Zhe Zhang,Balázs Győrffy,Saraswati Sukumar

Induction of cell cycle arrest and inflammatory genes by combined treatment with epigenetic, differentiating, and chemotherapeutic agents in triple-negative breast cancer

2018

Vanessa F. Merino
Soonweng Cho
Nguyen Nguyen
Helen Sadik
Athira Narayan
C. Conover Talbot
Leslie Cope
Xian C. Zhou
Zhe Zhang
Balázs Győrffy
Saraswati Sukumar

Background A combination of entinostat, all-trans retinoic acid, and doxorubicin (EAD) induces cell death and differentiation and causes significant regression of xenografts of triple-negative breast cancer (TNBC).

Keywords:

Breast cancer
Cancer research
Entinostat
Doxorubicin
Programmed cell death
Triple-negative breast cancer
Immunotherapy
Medicine
Retinoic acid
Epigenetics
Immune checkpoint
Cell cycle checkpoint
Cancer/testis antigens

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