A plant recombinant human CTLA4Ig and a method for producing the same

The invention β1,4- human galactosyl recombinant vector pBI-3D-hGalT or containing the gene transfer raise pBI-35S-hGalT; hCTLA4Ig recombinant vector pMYN414 and the recombinant vector pBI-3D-hGalT or transformed cell lines by a pBI-35S-hGalT containing a fusion protein gene; And providing them with a method for producing a fusion protein prhCTLA4Ig (plant recombinant human CTLA4Ig) having a human glycan structure. prhCTLA4Ig fusion protein of plant cell-derived having a human glycan structure produced in accordance with the present invention because of the presence of human glycan structure produces an improved in vivo half-life compared to conventional plant-derived proteins. Thus the invention makes it possible to mass-produce prhCTLA4Ig fusion protein having an immunosuppressive activity hCTLA4Ig equal to the fusion protein expressed in conventional animal cell using a plant expression system, at the expense of cost. CTLA4Ig, galactosyl transferase raised, plants, sugar