Derivatives of N- (1H-indol-5-yl) naphthalene-1-sulfonamide and related compounds as serotonin receptor antagonists 5HT 6 for the treatment of disorders of the central nervous system.

A compound sulfonamide derivative of general formula (I) ** (See formula) ** in which A represents a substituent selected from: ** (See formula) ** R 1 represents hydrogen, an alkyl radical C 1-C 4 or a benzyl radical; n represents 0, 1, 2, 3 or 4; R2 represents -NR4R5 or a group of formula: ** (See formula) ** R3, independently represent hydrogen or C 1-C 4 alkyl; R4 and R5 independently represent a C1-C4 alkyl, X, Y and Z independently represent hydrogen, fluorine, chlorine, bromine, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, trifluoromethyl, cyano, nitro and -NR 4R5 ; W represents a bond between the two rings, CH2, O, S and NR4; m represents 0, 1, 2, 3 or 4; with the proviso that when m = 0, A is a substituted phenyl; or a physiologically acceptable salt thereof.