Bioactivation of biomorphous silicon carbide bone implants

Abstract Wood-derived silicon carbide (SiC) offers a specific biomorphous microstructure similar to the cellular pore microstructure of bone. Compared with bioactive ceramics such as calcium phosphate, however, silicon carbide is considered not to induce spontaneous interface bonding to living bone. Bioactivation by chemical treatment of biomorphous silicon carbide was investigated in order to accelerate osseointegration and improve bone bonding ability. Biomorphous SiC was processed from sipo ( Entrandrophragma utile ) wood by heating in an inert atmosphere and infiltrating the resulting carbon replica with liquid silicon melt at 1450 °C. After removing excess silicon by leaching in HF/HNO 3 the biomorphous preform consisted of β-SiC with a small amount (approximately 6 wt.%) of unreacted carbon. The preform was again leached in HCl/HNO 3 and finally exposed to CaCl 2 solution. X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared analyses proved that oxidation of the residual carbon at the surface induced formation of carboxyl [COO − ] groups, which triggered adsorption of Ca 2+ , as confirmed by XPS and inductively coupled plasma optical emission spectroscopy measurements. A local increase in Ca 2+ concentration stimulated in vitro precipitation of Ca 5 (PO 4 ) 3 OH (HAP) on the silicon carbide preform surface during exposure to simulated body fluid, which indicates a significantly increased bone bonding activity compared with SiC.