Effect of Sonic Hedgehog signaling pathway on pulmonary fibrosis

The role of Sonic Hedgehog(SHH)signaling pathway in embryonic lung development has been recognized.What's more, it also plays a key role in postnatal development and maintenance of tissue or organ integrity and function.In recent years, studies have found that SHH signaling pathways are involved in the lung repairing process, suggesting that SHH signaling pathways may play a role in pulmonary fibrosis.This paper reviews the effect of the SHH signaling pathway in pulmonary fibrosis. Key words: Hedgehog, Sonic; Pulmonary fibrosis