Synthesis, structural characterization, antimicrobial, DNA-binding, and photo-induced DNA cleavage activity of some bio-sensitive Schiff base copper(II) complexes
2010
Schiff base mixed-ligand copper complexes [CuL1(phen)Cl2], [CuL1(bipy)Cl2], [Cu(L1)2Cl2], [Cu(L2)2Cl2], [CuL2(bipy)Cl2], and [CuL2(phen)Cl2] (where L1 = 4-[3,4-dimethoxy-benzylidene]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazole-3-one; L2 = 4-[3-hydroxy-4-nitro-benzylidene]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazole-3-one; phen = 1,10-phenanthroline; and bipy = 2,2′-bipyridine) have been synthesized and characterized. Their DNA-binding properties have been studied by electronic absorption spectra, viscosity, and electrochemical measurements. The absorption spectral and viscosity results suggest that the copper(II) complexes bind to DNA via partial intercalation. The addition of DNA resulting in the decrease of the peak current of the copper(II) complexes indicates their interaction. Interaction between the complexes and DNA has also been investigated by submarine gel electrophoresis. The copper complexes cleave supercoiled pUC19 DNA to nicked and linear forms through hydroxyl radical and singlet oxygen in th...
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