The Chicken or the Egg: MicroRNA-Mediated Regulation of mRNA Translation or mRNA Stability
2009
In this issue of Molecular Cell , Fabian et al. (2009) demonstrate that in cell-free extracts from mouse Krebs-2 ascites, microRNA-mediated translational repression precedes target mRNA deadenylation, and identify GW182, PABP, and deadenylase subunits CAF1 and CCR4 as factors required for deadenylation.
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