Oxidative Stress in the Tumor Immune Microenvironment

Oxidative stress is one of defining features of the tumor microenvironment, which is closely related to the interactions between tumor cells and stromal cells. It affects tumor progression in many aspects. In the tumor microenvironment, primary immune cells have different functions, which together make up the immune defense line of the tumor. This review focuses on the relationship between oxidative stress and tumor-related immune system, specifically the effects and mechanisms of oxidative stress on different cell processes of immune cells in the tumor microenvironment. Then, we discuss the main overall effect of oxidative stress, immunosuppression, and its inspiration for tumor immunotherapy, which provides a theoretical basis for the feasibility of oxidative stress as a new target of tumor immunotherapy.