Mycotoxins and female reproduction: in vitro approaches

Exposure to mycotoxins has been linked to adverse effects on female reproduction by interfering with the synthesis, metabolism or degradation of steroid hormones, interaction with steroid receptors or impairing oocyte maturation and competence. To assess such effects, many studies initially focussed on possible endocrine actions of mycotoxins using specific cell lines known to express key enzymes involved in the synthesis of steroid hormones. Using these models, zearalenone, deoxynivalenol, ochratoxin A, T-2 and HT-2 toxins, and aflatoxin B1 were claimed to be endocrine active substances. As yet, zearalenone is the only mycotoxin for which a direct interaction with oestrogen receptors could be demonstrated, classifying this mycotoxin as an endocrine disruptor. Mycotoxin exposure of complex cell systems like ovarian follicles at the earliest (primordial) to most advanced (pre-ovulatory) stages can serve not only as the first indication of the potential of a mycotoxin to affect female reproduction, but also...