Treatment of diabetes by the intrathecal transplantation of islet-like cell clusters

Multi-intrathecal allo-transplantation of islet-like cell cluster(ICCs,islets:2×103～10×103)from multi-donors into alloxan-diabetic rabbits significantly reduced the blood sugar level in 50% recipients(P<0.05).30% of them remained in the state of normoglycemia for up to 2 years.No rejection response and abnormalities were found in CNS of patients.Histological examination showed presence of a lot of islet clusters on the surfaces of brain,ventricles and spinal cord but absence of lymphocytic infiltration.Our study provided a new approach for the treatment of diabetes. Key words: Islands of langerhans; Transplantation; Diabetes mellitus,experimental