Recent Advances in β-L-Rhamnosylation
2020
L-Rhamnose forms the key components of important antigenic oligo- and polysaccharides of a variety of pathogens. Obtaining 1,2-cis stereoselectivity in glycosylation of L-rhamnoside is quite challenging due to unavailability of neighboring group participation, disfavoring of anomeric effect and stereoelectronic effect of the substituents on the C-2 axial position. Nevertheless, various methodologies have been developed exploiting diverse pathways for obtaining β-stereoselectivity in glycosylation of L-rhamnose. This review describes the recent advances in β-L-rhamnosylation and its applications in the total synthesis of β-L-rhamnose containing biologically important oligosaccharides.
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