Early Volume Expansion Improves the Outcome of Shigatoxin-Associated Hemolytic Uremic Syndrome. Data from the North Italian HUS Network

Shiga toxin E. coli hemolytic uremic syndrome (STEC-HUS) is a severe acute illness for which there is no specific treatment and among supportive care, fluid management is traditionally concentrated on preventing fluid overload because the patients often present with oligo/anuric acute kidney injury. Hemoconcentration at the time of onset is associated with more severe disease, but it is still unknown whether early volume expansion can improve disease outcomes. A network of pediatric hospitals has been operating since May …