Ceftizoxime alapivoxil synthesized from cephalosporin drug intermediate and preparation method thereof

The invention relates to ceftizoxime alapivoxil synthesized from a cephalosporin drug intermediate and a preparation method thereof. The preparation method effectively solves the problems that the existing active ester synthesis method adopting a promoter DM produces residues and has a high cost, poor quality and low efficiency. The preparation method comprises the following steps that (z)-2-(2-aminothiazole-4-yl)-2-methoxyl iminoacetic acid and a hydroxyl compound are prepared into an active ester; the active ester prepared from the hydroxyl compound undergoes a condensation reaction with 7-amino-3-nor-3-cephem-4-carboxylic acid (7-ANCA) to produce (6R,7R)-7-[(2-amino-4-thiazolyl)-methoxylimine]acetamido-8-oxo-[4.2.0]oct-2-ene-2-carboxylic acid; the (6R,7R)-7-[(2-amino-4-thiazolyl)-methoxylimine]acetamido-8-oxo-[4.2.0]oct-2-ene-2-carboxylic acid and a halogenated methyl trimethylacetate undergo a reaction in the presence of an organic solvent to produce a ceftizoxime ester; the ceftizoxime ester and amino acids undergo a condensation reaction; and one or more protective groups are removed so that a desired compound is obtained. The preparation method is simple, stable and reliable, is easy for operation, does not produce residues in active ester synthesis adopting the promoter DM, has a low cost, good product quality and high efficiency, is beneficial for industrialized production, and has great economic benefits and social benefits.