Polarized Th2 Cells Attenuates High-Fat-Diet Induced Obesity Through the Suppression of Lipogenesis

Immune cells such as macrophages, B cells, neutrophils and T cell subsets are involved in obesity. However, the tissue-specific function of Th2 cells in adipose tissue remains unknown. We show here that adoptive transfer of polarized Th2 cells to CD3e knockout (CD3e —/—) mice attenuates obesity after high-fat-diet (HFD), accompanied by relieved hepatic steatosis, glucose intolerance, and insulin resistance. Mechanistically, Th2 cell treatment promoted oxidative phosphorylation of adipocytes, contributing to the decrease of lipid droplet accumulation. Our data indicate that Th2 cell treatment is a novel approach to the treatment of diet-induced obesity and other diseases involving lipid droplet accumulation disorders. Funding: This work was funded by the National Natural Science Foundation of China (Grant No. U1804190, 81871309) and the 111 Project (D20036, China) to Hui Wang. Declaration of Interest: The authors declare no conflicts of interest for this work. Ethical Approval: All animal experiments in this study were approved by the Welfare and Ethical Committee for Experimental Animal Care of Xinxiang Medical University.