Characteristics of TCM syndromes in 74 patients with chronic severe hepatitis B

Objective To investigate the regular pattern of traditional Chinese medicine(TCM) syndromes of chronic severe hepatitis B(CSHB),and to explore the correlations between syndrome differentiation and the related laboratory markers and the in cidence of complications.Methods Patterns of syndrome differentiation,the related laboratory markers and the incidence of thecomplications in CSHB patients hospitalized in Beijing You'an Hospital,Capital Medical University from Jul.2009 to Mar.2010 were retrospectively studied.Syndrome differentiation was made according to syndrome differentiation classification protocol formulated by the study on CSHB TCM syndrome law and integrated TCM and western medicine treatment protocol supported by the Major and Special Programs of National"Eleventh Five-Year Plan"Period and the correlations between the patterns of syndrome differentiation and the related laboratory markers and the incidence of complications were analyzed.Results Of 74 CSHB patients,the common CSHB TCM syndromes were Qi-deficiency jaundice(25.7%),Yang-deficiency jaundice(16.2%),hygropyretic jaundice(27.0%) and blood stasis-heat jaundice(21.6%).Yin-deficiency jaundice(9.5%) was seldom found.Laboratory markers such TBIL,PT,NEUT% and HGB were not significantly different among the patients with the 5 patterns of TCM syndromes.However,NEUT% of the deficient syndrome group was higher than that of the excessive syndrome group,and the difference between the two groups was significant.The incidence rates of ascites,hepatic encephalopathy,spontaneous bacterial peritonitis,electrolyte disturbance and hepatorenal syndrome were not significantly different among the patients with the 5 patterns of TCM syndromes.However,the incidence of ascites in the deficient syndrome group was higher than that in the excessive syndrome group,and the difference between the two groups was significant.Conclusions The laboratory markers and the incidence of complications are not significantly different among the patients with the 5 patterns of TCM syndromes.However,they are significantly different between the deficient syndrome group and the excessive syndrome group.CSHB TCM syndrome differentiation is correlated with laboratory markers and the incidence of complications,and the differentiation of deficient syndromes and excessive syndromes should be paid much attention to in clinical practice.